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pentobarbital decreases outcomes of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Coadministration of CYP3A4 inducers might lessen sufentanil stages and efficacy, potentially precipitating withdrawal syndrome in sufferers who've designed Bodily dependence to sufentanil. Discontinuation

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